Loss of function in mitochondria, the key organelle responsible for cellular energy production, can result in excess fatigue and other symptoms that are common complaints in almost every chronic disease. At the molecular level, a reduction in mitochondrial function occurs as a result of the following changes:
- A loss of maintenance of the electrical and chemical transmembrane potential of the inner mitochondrial membrane;
- Alterations in the function of the electron transport chain;
- A reduction in the transport of critical metabolites into mitochondria. In turn, these changes result in a reduced efficiency of oxidative phosphorylation and a reduction in production of adenosine triphosphate (ATP).
In its initial stages, mitochondrial dysfunction is reversible, enabling the life and health of cells to be prolonged at the molecular level. The key lies in early interventions to ensure optimal mitochondrial function before irreversible DNA damage occurs.
Clinical trials have shown the utility of using oral replacement supplements, such as L-carnitine, alpha-lipoic acid, coenzyme Q10 (CoQ10), magnesium and other supplements. Combinations of these supplements can reduce significantly the fatigue and other symptoms associated with chronic disease and can naturally restore mitochondrial function, even in long-term patients with intractable fatigue.
In this infographic explore an integrative nutritional approach to improving energy production and healthy ageing through the optimisation of mitochondrial function.
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