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Dissecting Chronic Fatigue: Part 1 with Dr Mark Donohoe

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PART 1: Dissecting Chronic Fatigue with Dr Mark Donohoe

References to an illness with symptoms strongly resembling those of chronic fatigue syndrome can be traced back to as early as 1750. By the 20th century, this condition gained more attention after a series of unexplained epidemics, causing weakness and fatigue, affected large numbers of people. By 1988 the term chronic fatigue syndrome (CFS) was developed as working case definition of the illness.

Given that there was no clear biological mechanism, CFS has often been claimed to have a psychological cause and many clinicians have long been sceptical over its existence as a disease entity, often concluding that the disorder is, quite literally, “in a person’s head.”

In more recent years robust evidence that chronic fatigue syndrome is in fact, a biological illness has emerged. Researchers have identified distinct immune and brain changes in patients diagnosed with chronic fatigue syndrome.

Dr Mark Donohoe has been working with CFS patients for more than two decades. In this first instalment of a two-part podcast series, he discusses the history of CFS , the myriad of underlying contributing factors, how it differs from other types of fatigue, his own valuable clinical observations and much more.

Look out next week for Part 2

Covered in this Podcast

[00:58] Welcoming back Dr Mark Donohoe
[01:22] More than simply Chronic Fatigue Syndrome.
[02:46] Painting the typical patient picture.
[06:28] "It's all in their head"
[07:54] "No abnormality detected" - not fitting the "box"
[09:04] Adaptive response masking pathology
[12:32] Differentiating and diagnosing fatigue
[17:33] Finding the answers
[22:33] The evolution of disease
[29:09] Measuring function
[33:40] Stress proteins: sacrificing function for structure
[37:26] The "Why" comes from effective patient history-taking
[41:19] Modern-day predators
[41:58] There's a rise in CFS in our youth
[44:26] Uncovering the underlying factors
[50:50] Wrap up and looking ahead to Part 2 (and beyond).

Other Podcasts with Mark Include:


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Dr Mark Donohoe

Dr Mark Donohoe is one of Australia’s most experienced and best known medical practitioners in the fields of Nutritional and Environmental Medicine. He has a long history working in the emerging field of “integrative medicine”, and continues to bring orthodox and complementary medicine together in his medical practice. He is a regular guest on the FX Medicine Podcast and in 2019 became the host of FX Medicine's newest podcast series; FX Omics - blending genetics into the modern practice of personalised medicine.