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Magnesium Influences Vitamin D Status

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  • Magnesium Influences Vitamin D Status

Previous in vitro and in vivo studies have indicated that the enzymes required to synthesise and metabolise vitamin D are magnesium dependent. Recent observational studies have found that magnesium intake significantly interacts with vitamin D levels and risk of mortality.

In order to understand the interplay of magnesium and vitamin D in an era where the majority of adults do not meet their recommended daily intakes, a team of researchers tested the hypothesis that magnesium supplementation affects vitamin D metabolism dependent on baseline 25-hydroxyvitamin D [25(OH)D] concentration.

A double-blind, randomised, controlled study of 180 participants aged 40-85 years old tested the supplementation of either a personalised magnesium or placebo treatment on plasma concentrations of various vitamin D markers including 25 hydroxyvitamin D3 [25(OH)D3], 25-hydroxyvitamin D2 [25(OH)D2], 1,25-dihydroxyvitamin D3, 1,25-dihydroxyvitamin D2 and 24,25-dihydroxyvitamin D3 [24,25(OH)2D3].

Results found that magnesium supplementation interacted with baseline plasma concentrations of 25(OH)D in affecting the concentrations of 25(OH)D3, 25(OH)D2, and 24,25(OH)2D3. However, the required concentration of 25(OH)D for optimising vitamin D metabolite levels varied depending on the metabolite. For example, 25(OH)D3 and 24,25(OH)2D3 levels increased when 25(OH)D were at 30ng/mL, while 25(OH)D2 levels increased with increasing 25(OH)D levels from 30-50ng/mL.

The results of this study suggest that optimal magnesium status may be important for optimising 25(OH)D status, particularly in nutrient deficient populations.


  1. Dai Q, Zhu X, Manson JE, et al. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. Am J Clin Nutr 2018;108(6):1249-1258. [Abstract]


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Stephanie Radnan

Stephanie is a qualified naturopath, journalist, personal trainer, and multitasker who has been lucky to live her passion throughout her career in the realm of health and fitness. Currently, Stephanie is working as a writer and editor for one of Australia's leading nutraceutical companies. Outside of her work in comms and journalism, she owns her own naturopathy, health and fitness company specialising in mental health, gut health and female hormones. Health food, exercise and bringing people happiness are Stephanie’s biggest drivers in life, with travel, pets and adventure filling up her free-time.