When does tiredness become fatigue? How does the clinical picture change and how is a diagnosis reached?
Our ability to cope with stress depends largely on the complex interactions between components of our hypothalamic-pituitary-adrenal axis (HPA axis). The adrenal cortex figures prominently in the manifestation of adrenal fatigue due to disregulation of the production of cortisol. Adrenal fatigue is not widely medically recognised, and lies somewhere between the underactivity of Addison’s disease and the overactivity of Cushing’s Disease, where cortisol levels lie at the extremes.