Calcium D-glucarate: breast cancer & oestrogen clearance

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It has been well documented that good nutrition and a plant-based diet may reduce the incidence of breast cancer and the risk of breast cancer progression. Foods that provide carotenoids, diindolylmethane (DIM) and isothiocyanates (sulforaphane) have all been shown to have an inhibitory effect on breast cancer. Calcium D-glucarate is another key nutrient thought to confer protection against breast cancer via the reduction of oestrogen levels and pro-carcinogenic drugs that are subject to glucuronidation.

All steroid hormones, as well as toxins such as benzopyrene and polyaromatic hydrocarbon compounds, are detoxified via glucuronidation in the liver. Once in the gut, beta-glucuronidase, an enzyme produced by intestinal bacteria, can break the bond between the excreted toxin and glucuronic acid, increasing the formation of carcinogens in the bowel and promoting the enterohepatic recirculation of toxins, hormones and various drugs in the body. Elevated beta-glucuronidase activity is associated with an increased risk for various cancers, particularly hormone-dependent cancers such as breast, prostate, and colon cancers.

Oral supplementation of calcium D-glucarate has been shown to inhibit beta-glucuronidase, increasing excretion of toxins that are normally subject to glucuronidation. In this infographic we explore the potential protective benefits of calcium D-glucarate in relation to breast cancer and the mechanisms behind its therapeutic actions.

REFERENCES

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melissalee's picture
Melissa Lee
Melissa is a designer turned nutritionist, who for the past 6 years has been combining the two modalities to create purposeful designs for various health publications and websites. Having initially studied Multimedia Systems Design, she then went on to complete a BHSc in Nutritional Medicine which led to her involvement in the integrative medicine industry and eventually to FX Medicine.