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Fibromyalgia: pain, depression, stress

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Fibromyalgia (FM) is a common syndrome characterised by extensive, long-term pain and tenderness in muscles, joints, tendons and other soft tissues. Other features include non-restorative sleep, fatigue and psychological distress. Some patients report that their fatigue is more upsetting than their pain. 

While the cause is not fully understood, current research points to several underlying factors including abnormalities in the neuroendocrine and autonomic nervous systems, genetic factors, psychosocial variables and environmental stressors.

In recent years, the hypothesis that FM can be attributed to central sensitisation of nociception has also proved worthy of serious consideration. This widely researched theory demonstrates that FM is a condition caused by alterations in pain neuropeptides, especially substance P. There is increasing evidence suggesting that the use of specific nutritional supplements, such as S-adensylmethionine (SAMe), magnesium, coenzyme Q10 and activated vitamin B6, may prove useful in managing this multifactorial condition.

In this infographic we pay special attention to those key nutrients and provide a framework for their incorporation into a wider nutrient-based solution.


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Melissa Lee
Melissa is a designer turned nutritionist, who has combined the two modalities to create purposeful designs for various health publications and websites. Having initially studied Multimedia Systems Design, she then went on to complete a BHSc in Nutritional Medicine which led to her involvement in the integrative medicine industry and eventually to FX Medicine.