Recognising the future clinical implications of methylation dysfunction and the MTHFR gene early on, Carolyn Ledowsky started MTHFR Support Australia and hasn't looked back.
Taking an in-depth look at the background, key benefits, clinical applications and mechanisms of action of the various forms of folate available in therapeutics and food.
Imbalances in methylation pathways may be behind the pathogenesis of a range of health conditions. So what actually, is Methylation?
Methylation Assessment using Functional Pathology. Why should we do it and what does, and doesn't it tell us about our health?
This study provides strong evidence of the efficacy of folic acid and methylcobalamin for the treatment of common folic acid and vitamin B12 deficiency signs and symptoms.
One potential mechanism proposed for the pathogenesis of preeclampsia is elevated homocysteine levels adversely affecting placental functionality, with various data finding a three- to eightfold increase in risk of disease onset associated with hyperhomocysteinaemia.
"The success of antidepressant drug therapy is not high, with studies suggesting 19-60% of patients are unresponsive to the treatment". Optimal methylation seems to be one very important piece of the mood puzzle.
Homocysteine is an intermediate produced in the metabolism of sulfur-containing amino acids. Elevated levels of homocysteine are associated with heart attack, heart disease, vascular disease as well as dementia and cognitive decline, macular degeneration, migraine, neural tube defects and bone fractures.