S-adenosylmethionine (SAMe) is integral to cellular metabolism and as the major methyl donor in the body. SAMe is involved in the methylation of a diverse range of compounds including phospholipids, DNA, RNA, proteins and neurotransmitters. It is also involved in two other important pathways – transsulfuration which produces glutathione, and aminopropylation which synthesises polyamines.
The first Australian Summit on Methylation will take place in Melbourne in August 2017.
Taking an in-depth look at the background, key benefits, clinical applications and mechanisms of action of the various forms of folate available in therapeutics and food.
It seems that everywhere we look these days, there is something being written or spoken about MTHFR or methylation. However, should we be relying on this as a single focus for treatment?
Serum levels of vitamin B12 play an important role in cognitive and mental health. Observational studies have found as many as 30% of patients hospitalised for depression to be deficient in vitamin B12.
Imbalances in methylation pathways may be behind the pathogenesis of a range of health conditions. So what actually, is Methylation?
Methylation Assessment using Functional Pathology. Why should we do it and what does, and doesn't it tell us about our health?
"The success of antidepressant drug therapy is not high, with studies suggesting 19-60% of patients are unresponsive to the treatment". Optimal methylation seems to be one very important piece of the mood puzzle.